Three resin glycosides isolated from Argyreia acuta, including two isomers / 中国天然药物

In the present study, three compounds were isolated from Argyreia acuta, among them, compounds 1 and 2 were new and Compounds 1 and 3 were isomers. They were separated by several types of columns, such as normal phase, RP, size exclusion and preparative HPLC, and their structures were elucidated by several spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS.

Three resin glycosides isolated from Argyreia acuta, including two isomers / 中国天然药物

In the present study, three compounds were isolated from Argyreia acuta, among them, compounds 1 and 2 were new and Compounds 1 and 3 were isomers. They were separated by several types of columns, such as normal phase, RP, size exclusion and preparative HPLC, and their structures were elucidated by several spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS.

Establishment and effects of the system for consumable materials distribution based on closed loop supply chain in operating room / 中华护理杂志

Objective To establish and evaluate the system for consumable materials distribution based on closed loop supply chain in operating room.Methods The system improvement team was formed and current weaknesses of distribution system were analyzed,and the system for consumable materials distribution based on closed loop supply chain in operating room was established,using forward-supply and backward-supply distribution management.The statistics about surgical materials preparation time,materials supply time,connective time,pieces of daily returned materials,rate of nurses on-site in 2015 and 2016 were retrospectively analyzed to compare differences before and after application of the system.Results After application of the system for consumable materials distribution based on closed loop supply chain,surgical materials preparation time was reduced from 16.36±8.08 min to 10.33±5.75 min,materials supply time was reduced from 4.50±1.36 min to 2.98±1.03 min,connective time was reduced from 21.38±9.58 min to 19.78±7.64 min,pieces of daily returned materials were reduced from 119.47± 34.79 to 112.24±37.76,rate of nurses on-site was increased from 82.80％ to 84.90％,and all differences were significant(P＜0.05).Conclusion The system for consumable materials distribution based on closed loop supply chain in operating room combines forward-supply and backward-supply,can reduce surgical materials preparation time and materials supply time,fasten connective time which improves efficiency;the system can reduce pieces of daily returned materials,reduce consumable materials wastage during logistics,ensure the safety of the consumable materials,and improve the standardized management;the system can improve rate of nurses on-site,guarantee patients' safety during surgeries,and improve nursing quality in operating room.

Progress of serum pharmacochemistry of traditional Chinese medicine and further development of its theory and method / 中国中药杂志

Serum pharmacochemistry of traditional Chinese medicine (TCM) is designed to screen the efficacy material base of TCMs from the constituents absorbed into the blood after oral administration. The theory and method is in accordance with the effect characteristics of TCMs, and reflects the interaction between the body and the drugs, has become an effective pathway for researching the efficacy material base of TCMs which has been recognized and used widely. In the paper, the previous research contents and methods of the serum pharmacochemistry of TCM were reviewed, and on the basis of the further validity of the special administration form of the TCM formula and the corresponding property to TCM syndrome, the new strategy of serum pharmacochemistry of TCM integrating the metabonomics technologies was put forward. According to the strategy, we take the biological characters of TCM syndrome as a research starting point, taking TCM formula as object, using the metabolic biomarkers of syndromes or disease to evaluate the therapeutic effect of formula and screen the compounds of TCMs in serum which are highly correlated with the metabolic biomarkers through the correlation analysis, and by further biological validation to finally confirm the efficacy material basis of TCMs. Integrating with the systems biology technologies, the theory and method of serum pharmacochemistry of TCM will further develop, and open a new chapter in the interpretation of the theory of TCM.

Applications and approved projectsof general program, young scientist fund and fund for less developedregion of national natural science funds in discipline of Chinese materia medica, NSFC in 2012 / 中国中药杂志

The applications accepted and approved by general program, young scientist fund and fund for less developed region of national natural science funds in the discipline of Chinese materia medica, NSFC in 2012 have been introduced. The research contents of the funded projects in the popular research areas have been summarized and the problems in the applications have been analyzed to give a reference to the scientists in the field of Chinese materia medica.

Metabolomics and proteomics approaches to characterize and assess proteins of bear bile powder for hepatitis C virus / 中国天然药物

Metabolomics represents an emerging and powerful discipline that provides an accurate and dynamic picture of the phenotype of bio-systems through the study of potential metabolites that could be used as therapeutic targets and for the discovery of new drugs. Hepatitis C virus (HCV) is a leading cause of liver disease worldwide, and is a major burden on public health. It is hypothesized that an animal model of HCV infection would produce unique patterns of endogenous metabolites. Herein, a method for the construction of efficient networks is presented with regard to the proteins of bear bile powder (PBBP) that protect against HCV as a case study. Ultra-performance liquid chromatography, coupled with electrospray ionization/quadrupole-time-of-flight high definition mass spectrometry (UPLC-HDMS), coupled with pattern recognition methods and computational systems analysis were integrated to obtain comprehensive metabolomic profiling and pathways of the large biological data sets. Among the regulated pathways, 38 biomarkers were identified and two unique metabolic pathways were indicated to be differentially affected in HCV animals. The results provided a systematic view of the development and progression of HCV, and also could be used to analyze the therapeutic effects of PBBP, a widely used anti-HCV medicine. The results also showed that PBBP could provide satisfactory effects on HCV infection through partially regulating the perturbed pathway. The most promising use in the near future would be to clarify the pathways for the drugs and obtain biomarkers for these pathways to help guide testable predictions, provide insights into drug action mechanisms, and enable an increase in research productivity toward metabolomic drug discovery.

Influence of gentian leaf blight on the output and quality of Chinese gentian / 中国中药杂志

<p><b>OBJECTIVE</b>To study the influecnce of gentian leaf blight on the output and quality of rough gentian.</p><p><b>METHOD</b>The same grade seedlings were transplanted, disease of every plant was investigated in autumn and the output of gentian was determined. HPLC was applied to determine the content of gentiopicroside and swertiamarin.</p><p><b>RESULT</b>The output decreased with the aggravation of the disease, and the decrease was obvious when the index of disease was above 60. The content of gentiopicroside and swertiamarin began to drop when the index of disease was above 70.</p><p><b>CONCLUSION</b>The loss of output and the drop of quality are relatively heavy when the disease is serious. The loss of income is not obvious when the index of disease is under 60.</p>